Psychopathology and 5-hydroxyindoleacetic acid excretion

Psychopathology and 5-hydroxyindoleacetic acid excretion.

CONSIDERABLE indirect evidence, associating serotonin with central nervous system function and the actions of important psychotropic drugs, led to suggestions192 of a relationship between serotonin metabolism and schizophrenia. Despite considerable effort, experimental support for this suggestion has been inconclusive. Among studies in this area are those on quantitative excretion, and variabil...

Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals.

OBJECTIVE A substantial proportion of individuals with autism have elevated levels of platelet serotonin (5-HT). We examined whether platelet hyperserotonemia is associated with increased gut 5-HT synthesis, altered 5-HT catabolism or altered melatonin production. METHODS Urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT was compared in 10 normoserotonemic and 10 hyperserotone...

Cerebrospinal homovanillic acid and 5-hydroxyindoleacetic acid in huntington's chorea.

Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease.

Chaliacombe, D. N., Brown, G. A., Black, S. C., and Storrie, M. H. (1972). Archives of Disease in Childhood, 47, 442. Increased excretion of 5-hydroxyindoleacetic acid in urine of children with untreated coeliac disease. 24-hour urine excretions of 5-hydroxyindoleacetic acid (5HIAA) have been measured in 13 children with coeliac disease before treatment. All were excreting more 5HIAA than an ag...

Daily cyclic changes in the urinary excretion of 5-hydroxyindoleacetic acid in patients with carcinoid tumors.

BACKGROUND Vasoactive peptides produced by neuroendocrine tumors can induce characteristic symptoms of the carcinoid syndrome (flushing, diarrhea, and wheezing). To what extent external factors provoke these symptoms and how excretion of 5-hydroxyindoleacetic acid (5-HIAA), the degradation product of serotonin, varies throughout the day remain unknown. In this study, we investigated whether sym...